| 摘要 |
acid derivs. of formula (I) and their salts are new: In (I) R1-R3=H, 1-6C alkyl, 3-7C alkoxyalkyl, aryl, aryl(1-6C)alkyl or aryloxy(1-6C) alkyl R4=1-4C fluoroalkoxy; R5=aryl, heteroaryl, aryl(1-4C) alkyl, heteroaryl(1-4C)alkyl, diary(1-4C)alkyl, heteroaryl -aryl(1-4C)alkyl or diheteroaryl(1-4C)alkyl; A=2-5C alkylene opt. substd. by 1-4C alkoxy or aryl. Pref. R1=R2=Me; R3=Me, Et or methoxyethyl; R4=phenyl, 2-methoxypheyl or benzhydryl; A=ethylene or propylene. 9 Cpds. (I), including 3-ethyl 5-(3-(4-(2-methoxy phenyl)-1- piperazinyl) propyl) 4-(2-difluoro methoxyphenyl) -1,4-dihydro-2,6-dimethyl pyridine-3,5 -dicarboxylate (Ia) are specifically claimed. |
