| 发明名称 |
Modified tissue plasminogen activator. |
| 摘要 |
<p>A modified t-PA having improved in vivo half-life is disclosed comprising in sequence a fibronectin finger-like domain F, a sequence of two K2 kringle regions and a serine protease region SP, wherein the first of said kringles is free of any glycosylation site and the second of said kringles has a single glycosylation site.</p> |
| 申请公布号 |
EP0311589(A1) |
申请公布日期 |
1989.04.12 |
| 申请号 |
EP19880870156 |
申请日期 |
1988.10.07 |
| 申请人 |
MONSANTO COMPANY |
发明人 |
BELL, LESLIE DAVID;MAYER, ERNEST JAY;PALMIER, MARK OLIVER;TOLUNAY, HANIFE ESER;WARREN, THOMAS GEORGE;WUN, TZE-CHEIN |
| 分类号 |
C12N9/64;A61K38/00;A61K38/46;A61P7/02;C12N5/10;C12N9/72;C12N15/09;C12P21/02;C12R1/91 |
主分类号 |
C12N9/64 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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