| 摘要 |
PURPOSE:To obtain the titled drug for external use, containing kojic acid or an ester thereof and a specific compound, such as azelaic acid or tropolone, having synergistic inhibitory action on melanization and capable of exhibiting more remarkable beautifying, whitening and anti-sunburn effects. CONSTITUTION:A drug for external use obtained by containing kojic acid or an ester thereof and a compound selected from azelaic acid, tropolone, lipoic acid, sorbic acid, glucosamine and derivatives thereof and tunicamycin, deoxynojirimycin, glutathione, cysteine, hydroquinone and derivatives thereof, chelidonic acid and lipoamide at 1:0.01-1:20, preferably 1:0.1-1:10 weight ratio of the former to the latter. The amount of both blended active ingredients if preferably within the range of 0.5-10wt.% for a cosmetic or 0.5-5wt.% for an ointment.
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