发明名称 |
LIPOSOMES WITH ENHANCED CIRCULATION TIME. |
摘要 |
A composition of liposomes which contain an entrapped pharmaceutical agent and are characterized by (a) liposome sizes predominantly between about 0.07 and 0.5 microns; (b) at least about 50 mole percent of a membrane-rigidifying lipid, such as sphingomyelin or neutral phospholipids with predominantly saturated acyl chains; and (c) between about 5-20 mole percent of a glycolipid selected from the group consisting of ganglioside GM1, saturated phosphatidylinositol, and monogalactosyl stearate. The liposomes show high blood/RES tissue distribution ratios, and are effective for drug administration to tumors via intravenous drug delivery. |
申请公布号 |
EP0296212(A4) |
申请公布日期 |
1989.03.23 |
申请号 |
EP19880900748 |
申请日期 |
1987.12.21 |
申请人 |
LIPOSOME TECHNOLOGY, INC. |
发明人 |
ALLEN, THERESA, M.;GABIZON, ALBERTO |
分类号 |
A61K;A61K9/127;A61K9/42;A61K9/52;B01J13/02;C07F9/10 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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