| 摘要 |
The invention relates to ecto- and endoparasitic milbemycins of formula I <IMAGE> (I) wherein R is methyl, ethyl, isopropyl or sec-butyl; R1 is hydrogen, fluorine or C1-C4 alkyl; R2 is one of the groups <IMAGE> in which formulae is a value from 2 to 6; X is oxygen or sulfur; R3 is halogen; and R4 is hydrogen, C1-C12 alkoxy, C3-C7cycloalkoxy or C2-C6alkenyloxy; or C1-C18alkyl which is unsubstituted or substituted by halogen, C1-C4alkoxy, hydroxy and/or COOG, G being hydrogen, an alkali metal cation or an alkaline earth metal cation; or R4 is C3-C7cycloalkyl which is unsubstituted or substituted by halogen and/or C1-C4alkyl; C2-C18alkenyl which is unsubstituted or substituted by halogen; C2-C18alkynyl which is unsubstituted or substituted by halogen; phenyl which is unsubstituted or substituted by halogen, C1-C4alkyl C1-C4alkoxy, nitro, cyano and/or C1-C4haloalkyl; or a 5- or 6-membered unsaturated or saturated heterocyclic ring system which contains one to three hetero atoms selected from the series consisting of nitrogen, oxygen and sulfur and which is unsubstituted or substituted by oxo and/or by one to three substituents selected from halogen, C1-C4alkyl, C1-C4alkoxy and/or C1-C4haloalkyl; to the use thereof in agriculture and to the preparation thereof by esterifying the 5-OH-milbemycins on which they are based. |
