PROCESS FOR PREPARING ACYLANINOPHENOL DERIVATIVES

摘要

Acylaminophenyl thiazolidinecarboxylates (I)[n=0- were prepd.. Thus, (COCl)2 was added to L-2-oxo-4-thiazolidinecarboxylic acid in MeCN/DFM and the mixt. was stirred at -10≦̸C, treated with 4-HOC6H4NHAc, and stirred at room temp. to give L-I (n=0) (II). (II) was an effective analgesic and had an antiinflammatory effect at an oral dose of 310mg/kg in the rat paw edema test.