| 摘要 |
NEW MATERIAL:A compound of formula I [M is 5-7 membered heterocyclic group which contains 2N atoms and may be substituted, on its cyclic carbon atoms, with alkyl and oxo; A is formula II (X<1>, X<2> are H, halogen, where they are not H simultaneously); B is formula III (R<1> is H, alkyl; R<2>, R<3> are H, or incorporate to form oxo; Y is NR<5>; R<4>, R<5> are H, aryl, aralkyl, alkyl); A, B are different substituents of M on N atoms]. EXAMPLE:1-[Bis(4-fluorophenyl)methyl]-4-(1-naphthylaminocarbonylmethyl )pipe razine. USE:Cerebral metabolism improver. It has excellent calcium-inhibiting action and hypoxia-antagonistic action. PREPARATION:The reaction of an amino compound of the formula: A-M-H with an alkylating agent of formula IV (Xa is halogen, alkanesulfonyl, or the like) gives the compound of formula I. |
