Inhibition of mineral deposition by polyanionic/hydrophobic peptides and derivatives thereof.

摘要

A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure: poly (X)n poly (Y)m where each X is a residue independently selected from the group consisting of aspartic acid, glutamic acid, phosphoserine, phosphohomoserine, phosphotyrosine, and phosphothreonine, each Y is independently a residue selected from the group consisting of alanine, leucine, isoleucine, valine and glycine, n is 2 to 60, m is 2 to 60, and n + m >/= 5, and wherein poly (X)n may contain up to 10% of the Y residues and poly (Y)m may contain up to 10% of the X residues, and salts thereof.