| 摘要 |
Compounds of the formula <IMAGE> (I) in which R represents a carbocyclic or heterocyclic aryl radical, R1 represents lower alkyl, one of the groups R2 and R3 represents lower alkyl and the other represents lower alkyl, cyano aor amino, X represents oxygen or the group -NH-, Alk1 represents lower alkylene or optionally substituted phenyl-lower alkylene, which separates the group X from the nitrogen atom by at least two carbon atoms, R4 represents hydrogen, lower alkyl or optionally substituted phenyl-lower alkyl, Z represents the group -(C=O)- or a single bond, Alk2 represents lower alkylene which separates the groups Z and Y preferably by from 2 to 4 carbon atoms, Y represents the group -(C=O)- and Ar1 represents a monocyclic, carbocyclic or heterocyclic aryl radical, and salts of such compounds having salt-forming properties, have cardiovascular properties, especially coronary dilatory and anti-hypertensive properties.
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