A SPONGE ENZYME HAVING TRANSGLUTAMINASE-LIKE ACTIVITY

摘要

The present invention relates to the isolation of a marine sponge enzyme having properties similar to transglutaminase, from the tissues of the marine sponge, specifically Microciona prolifera. Transglutaminases and transglutaminase-like substances such as this may be used in the treatment of bleeding disorders, such as hemophilia, or in the treatment of excess bleeding as may arise in a surgical or dental procedure. The transglutaminase may be administered alone or in the form of a sustained delivery vehicle, such as in liposomes, and alternatively, with or without fibronectin.