发明名称 BENZOTHIAZOLE AND BENZOTHIOPHENE DERIVATIVES
摘要 The invention relates to compounds of the general formula I <IMAGE> wherein R1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO2+L, CF3 or the group -NR5R6, whereby two substituents taken together may also represent a methylene-dioxy group, X represents nitrogen or the group <IMAGE> n has the value 0, 1 or 2, R3 represents one of the moieties: <IMAGE> <IMAGE> the latter meaning of R3 (amide) only under the condition that for X is nitrogen the meaning of R1 is limited to substituents selected from hydroxy, alkoxy(1-6 C) and methylenedioxy, and R4, R5 and R6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heart failure.
申请公布号 DE3567459(D1) 申请公布日期 1989.02.16
申请号 DE19853567459 申请日期 1985.03.06
申请人 AKZO N.V. 发明人 REDPATH, JAMES;LOGAN, ROBERT THOMAS;MCFADZEN, DAVID BRUNTON;ROY, ROBERT GIBSON
分类号 A61K31/38;A61K31/381;A61P9/04;C07D277/64;C07D277/68;C07D333/24;C07D333/32;C07D333/38;C07D333/42;C07D333/56;C07D333/58;C07D333/60;C07D333/62;C07D333/66;C07D333/68;C07D333/70;C07D495/04;(IPC1-7):C07D333/70;A61K31/425 主分类号 A61K31/38
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