发明名称 |
PRODUCTION OF DEUTERATED INNER ALKYNE COMPOUND |
摘要 |
<p>PURPOSE:To obtain an optically active 1-deuterated substance useful as a intermediate for perfume, drugs and liquid crystal compounds, by reacting (R)-5- benzyloxy-4-hydroxy-1-pentyne with deuterated DMSO in the presence of a base. CONSTITUTION:A compound shown by formula I or formula II (R is protecting group; asterisk is asymmetric carbon atom.) is reacted with deuterated DMSO in the presence of a base (e.g. potassium tertiary butoxide) at room temperature to give a compound shown by formula III (X1-X3 are H or heavy hydrogen and at least one of X1-X3 is heavy hydrogen). Since deuterated DMSO is also useful as a reaction solvent and preferably used in an extremely excess amount. After the reaction is over, treatment with heavy water increases yield of the aimed substance and improves substitution ratio of heavy hydrogen.</p> |
申请公布号 |
JPS6440438(A) |
申请公布日期 |
1989.02.10 |
申请号 |
JP19870194727 |
申请日期 |
1987.08.04 |
申请人 |
ADEKA ARGUS CHEM CO LTD |
发明人 |
TAKANO SEIICHI;OGASAWARA KUNIRO;SEKIGUCHI YOSHIISA |
分类号 |
C07C29/56;C07B59/00;C07C27/00;C07C33/044;C07C41/00;C07C41/18;C07C43/178;C07C67/00;C07D207/04;C07D307/12;C07D307/20;C07F7/18 |
主分类号 |
C07C29/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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