Continuous processes for modifying biologically active materials and the products therefrom.

摘要

Process for chemically modifying biologically active materials in a controlled, continuous, and reproducible manner. The chemical reaction occurs in a dynamic, liquid flow reactor having at least two port means. By controlling the introduction sites for modifying reagants and quenchers in conjunction with the rate of the flow, one can reproducibly alter the weight, size, or functionality of a biologically active material in accordance with molecular weight distribution ranges that would not have been possible with prior methods. The present process is especially suited for producing polymerized hemoglobin with oxygen transport capacity.