发明名称 |
IMPROVED PROCESSES FOR THE TREATMENT OF VASCULAR DISEASE |
摘要 |
Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-life of natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients. |
申请公布号 |
WO8900197(A1) |
申请公布日期 |
1989.01.12 |
申请号 |
WO1988US02175 |
申请日期 |
1988.06.27 |
申请人 |
GENENTECH, INC. |
发明人 |
HIGGINS, DEBORAH, L.;HOLMES, WILLIAM, E.;HOTCHKISS, ADAIR, J. |
分类号 |
C12N9/64;A61K38/46;A61P7/02;C07K1/107;C07K14/745;C12N5/10;C12N9/72;C12N15/09;(IPC1-7):C12N15/00;A61K37/547 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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