发明名称 |
PROCESS FOR PREPARING 7-AMINO-3-ACETOXYMETHYL- CEPH-3-EM-4-CARBOXYLIC ACID DERIVATIVES AND ANALOGUES |
摘要 |
<p>A process for preparing compounds of the formula I: <CHEM> wherein X is sulphur, oxygen, methylene or sulphinyl (R or S configuration), R<3> is hydrogen or methoxy, R<4> is an optionally substituted (1-4C) alkyl group, Y is hydrogen or a carboxyl protecting group and Q is an optionally protected amino group or an acylamino group, which comprises reacting a compound of formula (II) <CHEM> with a compound of formula (III) <CHEM> wherein R<4> is as defined above and W and Z represent hydrogen atoms or a group or groups removable to yield the compound of formula (I). The compounds of the formula I are useful intermediates in the preparation of cephalosporin antibiotics.</p> |
申请公布号 |
NZ220308(A) |
申请公布日期 |
1989.01.06 |
申请号 |
NZ19870220308 |
申请日期 |
1987.05.14 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
LOFTUS, F;PEGG, S.J.;SNAPE, E.W. |
分类号 |
C07D463/00;C07D498/04;C07D501/04;C07D501/18;C07D501/38;C07D501/46;C07D505/00;C07D507/04;C07D507/06;C07D507/08;(IPC1-7):C07D487/04;C07D498/00;C07D471/04 |
主分类号 |
C07D463/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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