| 摘要 |
A method for sensitizing mammalian tumor cells which comprises the step of inserting a drug sensitivity gene into the tumor cell. Also disclosed is the use of hypoxanthine phosphoribosyltransferase for the treatment of leukemia when the drug 6-thioguanine is used. The method employs a composition of matter which includes a 3 min long terminal repeat and a 5 min long terminal repeat, each repeat containing a restriction enzyme site; between the repeats is inserted a promoter and/or enhancer gene and the drug sensitivity gene. All of the elements of the DNA are linked and spatially positioned, such that, when the gene is inserted into a target cell the drug sensitivity gene is expressed. |
