| 摘要 |
PURPOSE:To obtain the titled sustained release pharmaceutical with markedly low manifestation ratio of side effects, such as flush, and severity thereof and remarkably high bioavailability, by using a water-soluble high polymer substance as a sustainedly releasing carrier. CONSTITUTION:A sustained release pharmaceutical obtained by adding a water- soluble high polymer substance selected from hydroxypropyl cellulose, CMC, methyl cellulose, pullulan, PVA, glucomannan, etc., as a sustainedly releasing carrier to a principal agent consisting of a nicotinic acid derivative selected from nicotinamide, nicomol, hepronicate, niceritrol, inositol hexanicotinate, tartaric acid nicotinic alcohol and nicotinic acid dl-alpha-tocopherol, as necessary, blending a lubricant, excipient, etc., and preparing the pharmaecutical by a conventional method. The water-soluble high polymer substance is preferably selected so as to prolong residence time in the stomach and the amount thereof contained is 10-99wt.%, especially 25-90wt.% based on the total weight of the pharmaceutical.
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