| 摘要 |
<p>Compounds There are described compounds of formula I, I in which either R2 represents hydrogen, alkyl or Ar2, and R3 represents hydrogen, alkyl or alkyl substituted by Ar3; or R2 and R3 together form the chain -(CH2)m-; R4 and R5, which may be the same or different, each independently represent hydrogen, halogen, Ar, alkyl, or alkyl substituted by Ar, Ar1, Ar2 and Ar, which may be the same or different each independently represent aryl or aryl substituted by one or more of halogen, hydroxy, -CN, -COR6, trihalomethyl, alkoxy, alkoxy substituted by -COR6, alkoxy substituted by -NR7R8, alkyl, alkyl substituted by -COR6, alkyl substituted by NR7R8, alkoxy substituted by Ar3, S(O)nR9, -NR7R8 or OAr3; R6 represents -OR10, -NR7R8, hydrogen or alkyl; R7 and R8, which may be the same or different, each independently represent hydrogen, alkyl, alkanoyl or Ar3; R9 represents alkyl or Ar3; R10 represents hydrogen, alkyl or Ar3; m represents an integer from 3 to 6 inclusive; n represents 0, 1 or 2; and Ar3 represents unsubstituted aryl; or a pharmaceutically acceptable derivative thereof. There are also described compositions containing the compounds and methods for their preparation. The compounds are indicated for use as pharmaceutical, e.g. anti-inflammatory, agents.</p> |
