9-fluoroprostaglandin derivatives, their preparation and use as medicinal agents

摘要

9-fluoroprostane derivatives of Formula I <IMAGE> (I) wherein R1 is CH2OH or <IMAGE> wherein R2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R1 is the residue <IMAGE> wherein R3 is an acid residue or R2 and A is -CH2-CH2- or cis-CH=CH-, B is -CH2-CH2-, trans-CH=CH- or -C 3BOND C, W is a free or functionally modified hydroxymethylene group wherein the OH-group can be in the alpha - or beta - position, D and E jointly are a direct bond or D is straight-chain or branched alkylene or alkenylene of 1-10 carbon atoms which can optionally be substituted by fluorine atoms, and E is oxygen or sulfur, a direct bond, -C 3BOND C- or -CR6=CR7- wherein R6 and R7 differ from each other and each is hydrogen, chlorine, or alkyl, R4 is a free or functionally modified hydroxy group, and R5 is hydrogen, an optionally substituted aliphatic group, e.g., alkyl or halosubstituted alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group, and, when R2 is H, the physiologically compatible salts thereof with bases, have valuable pharmacological properties, e.g., as luteolytics or abortifacients.