SYNTHETIC ST TOXIN, PROCESS FOR ITS PREPARATION AND ITS USE AS A VACCINATING AGENT

摘要

The invention relates to novel synthetic peptides, process for their preparation and their application to the production of antibodies. These peptides include at the most 18 amino-acids and at the least 4 amino-acids in which n is equal to 1 or 2, and when n equals 1 the peptidic sequence P is contained in the following peptidic chain: Asn-Thr-Phe-Tyr-Cys-Cys-Glu-Leu-Cys-Cys-A-Pro-Ala-Cys- Ala-Gly-Cys-T in which either A represents Asn and T represents Tyr, or A represents Tyr and T represents Asn and in which the thiol groups of the possible cysteyl residues are protected by groups stable under biological conditions. Use for the production of antibodies capable of replacing biological activity particularly of enterotoxins produced by Escherichia coli strains.