| 摘要 |
NEW MATERIAL:A compound (salt) expressed by formula I (X is H, OH or oxo; the dotted line is single bond or double bond; R<1> is 1-8C alkyl, 2-8C alkenyl, etc.; R<2> is H, alkyl, alkenyl, aryl, etc.; R<3> is H, lower alkyl, carboxy- substituted lower alkyl, etc.; n is 0 or 1). EXAMPLE:13-(4-Fluorophenoxy)acetyloxy-5-ketomilbemycin A4-5-oxime. USE:A miticide, insecticide and helminthic agent. PREPARATION:For example, 13-substituted-5-ketomilbemycins expressed by formula II are reacted with hydroxylamine to convert the 5-position in the milbemycins into an oxime and the resultant oxime part is reacted in the presence of a base such as acid halide, etc., to give the compound expressed by formula I. |
