| 摘要 |
A process is provided for the production of N-substituted morpholines and piperidines of the formula <IMAGE> I comprising the steps of (a) reacting a methallylbenzene of the formulas <IMAGE> II wherein R1 is H or a straight or branched chained C1-C4 alkyl group, alone or in admixture with a corresponding isobutenylbenzene of the formula <IMAGE> III wherein R1 is as defined above, with hydrogen bromide in the presence of a peroxide to yield, respectively, the corresponding bromine compound of the formula <IMAGE> IV wherein R1 is as defined above, alone or in admixture with a bromine compound of the formula <IMAGE> V wherein R1 is as defined above and wherein the bromine atom is in the secondary or tertiary position, and (b) reacting the resultant bromine compound of formula IV, alone or in admixture with the corresponding bromine compound of Formula V, with a compound of the formula <IMAGE> VI wherein R2, R3, R4 and R5 are each independently hydrogen, methyl or ethyl and X is as indicated above.
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