HUMAN t-PA(u-PA) SUBSTITUTION-MUTANT PROTEINS, RECOMBINANT DNA CODING THEREFOR, TRANSFECTED HOST CELLS, PREPARATION OF THE MUTANT PROTEINS, AND PHARMACEUTICAL COMPOSITIONS

摘要

This invention relates to recombinant proteins built up from a portion of human tissue-type plasminogen activator (t-PA) and a portion of human urokinase (u-PA). The t-PA portion comprises the H chain or a modified H chain of t-PA, and the u-PA portion comprises the B chain of u-PA. The L chain of t-PA and A chain of u-PA are in essence absent. The invention also relates to recombinant genetic information coding for this recombinant proteins, a process for preparing the recombinant proteins, and pharmaceutical compositions comprising a recombinant protein according to the invention.