| 摘要 |
PURPOSE:To obtain economically and efficiently the titled granules having improved physical properties, e.g. solubility and dispersibility, etc., by adding a specific amount of water to aspartyl-phenylalanine methyl ester crystals, mixing them, and granulating the resultant mixture. CONSTITUTION:Water is added and mixed with (A) alpha-L-aspartyl-L-phenylalanine methyl ester crystals to give 35-45% moisture content in the crystals, and the resultant mixture is then granulated. The kneaded material is passed through a screen having 0.8-2mm. diameter and dried to afford the aimed granules. Type IIor II' is preferred for the component (A). |
