PREPARATION PROCESS FOR AMIDINO PEPERIDIEN DERIVATIVES

摘要

Title compds. (I)[n=0-3, Z=O, S; R=H, naphtyl, indanyl, pyridyl, tetrahydronaphthyl, Ph, biphenylyl, halo, alkyl, alkenyl, alkoxy, cyane, formyl, trifluoromethyl, phenylalkyl, or [(benzhydryloxycarbonylivinyl)phenyl, etc. were prepd. and showed complement inhibitor activity. Thus, 1-amidino-4piperidinepropionic acid.HCl was reacted with (PhO)2SO to give I.HCl (R=Ph, Z=O, n=2).