ELECTROENZYMATIC METHOD FOR PRODUCING COMPOUNDS HAVING A CONTROLLED ENANTIOMERIC PURITY

摘要

The method provides for the preparation of a compound having a controlled enantiomeric purity, respectively D-P or L-P, from a substrate S consisting of the oxidized form of the corresponding racemic D/L-P, or of said racemic D/L-P, or of the optical isomer inverse to the isomer to be prepared. According to said method, respectively said substrate S, said racemic D/L-P or the optical isomer inverse to the isomer to be prepared, as well as an oxidoreductase enzyme capable of catalyzing the oxidation of the optical isomer inverse to the isomer to be prepared are introduced into an electrochemical reactor. A potential difference is applied between the electrodes in order to carry out the non-stereospecific cathodic reduction of said substrate S, up to obtaining the isomer having the enantiomeric purity desired. The co-substrate of said enzyme is regenerated by anodic oxidation into said electrochemical reactor.