| 摘要 |
<p>IMPROVED METHODS FOR DISINFECTING AND PRESERVING CONTACT LENSES Improved methods of disinfecting and/or preserving contact lenses comprises treating said lenses with an effective concentration of a solution comprising a biguanide or a water soluble salt of the formula: wherein R1 and R3 are selected hydrogen, halogen, alkyl, alkoxy, nitro, -SO2R4, carboxyl or hydroxyl where R4 is -NH2, -NHR', -NR'R'', -OR' or -0-aryl in which R' and R'' are alkyl or alkoxy; R2 is hydrogen or halogen and X is hydrogen or alkyl, provided that when R2 is halogen then both R1 and R3 are hydrogen and X is alkyl. The method provides for disinfecting and/or preserving contact lenses wherein the monomeric biguanide-containing solutions offer a wide spectrum of antimicrobial activity with nominal binding and concentrating onto lens surfaces and low levels of eye tissue irritation or inflammation.</p> |
