| 摘要 |
<p>Certain beta-lactam epoxides have been found to be irreversible inhibitors of beta-lactamase enzymes, thus making them alternatives to clavulanic acid and sulbactam, and others are useful intermediates in the preparation of such compounds. These epoxides have general formula (21), wherein R represents the residue of a penicillin or cephalo sporin ring; X represents a hydrogen or halogen atom; V represents a halogen atom (intermediates) or a group A defined below (final products); and A represents a hydroxy, alkoxy, aryloxy, aralkyloxy, or alkyl group or an amino group, and their pharmaceutically acceptable salts.</p> |
