发明名称 |
USE OF VINYL ALCOHOL HOMOPOLYMERS AND COPOLYMERS FOR TABLETING ACTIVE MATERIALS |
摘要 |
Method of making tablets for active ingredient delivery by compressing a mixture of active ingredient and granular, high viscosity, fully hydrolyzed polyvinyl alcohol or copolymer of vinyl alcohol with methyl acrylate or methyl methacrylate. By use of a crystalline, heat treated polymer, a tablet providing quick active ingredient release is obtained. By using an amorphous, non-heat treated polymer a tablet providing prolonged active ingredient release is obtained. By using blends of crystalline and amorphous polymers, tablets having a range of active ingredient release characteristics can be obtained. The granular, high viscosity, fully hydrolyzed polymers provide flowability, compressibility and processing versatility advantages over conventional tablet binders. |
申请公布号 |
WO8807366(A1) |
申请公布日期 |
1988.10.06 |
申请号 |
WO1988US00696 |
申请日期 |
1988.03.23 |
申请人 |
E.I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
BATEMAN, LINDA, R.;COFFIN-BEACH, DAVID, P.;DI LUCCIO, ROBERT, C.;STEWART, CLARE, A., JR.;VISIOLI, DONNA, L. |
分类号 |
A61K9/20;A61K9/22;A61K47/32;C11D17/00;(IPC1-7):A61K9/22 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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