| 摘要 |
PURPOSE:To shorten the time required for hybrid and to improve hybrid effi ciency and labeling efficiency by forming a titled probe in such a manner that the heterologous single chain DNA fragments complementary with the different sections in the DNA or RNA to be detected are respectively labeled. CONSTITUTION:The heterologous single chain DNA fragments complementary with the different sections in the DNA or RNA to be detected consist respectively of the labeled plural heterologous DNA fragments. This DNA or RNA is the DNA or RNA derived from microorganisms such as hepatitis virus, AIDS virus, herpes virus and animal and vegetable cells in which the individual fragments have complementarity overall with the base sequence of DNA, RNA in a widest possible range. The resulted single chain can be labeled by an ordinary method. The DNA or RNA of the virus, etc., is detected by using this probe. Then, the time required for the hybrid is shortened and the hybrid efficiency and the labeling efficiency are improved.
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