| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R<1> and R<2> are phenyl or heterocyclic group; R<3> is H, alkyl or cycloalkyl; R<4> is H, CN, alkyl, cycloalkyl, aryl or heterocyclic group; R<5> and R<6> are H, halogen, CN, NO2, acyl, alkoxy, aryloxy, alkylthio, alkyl, aryl, etc.; R<4> and R<6> together with C to which they are linked may form 5--7-membered cycloalkenyl ring; R<5> and R<6> together with C to which they are linked may form 3--8-membered cycloalkyl ring) and salt thereof. EXAMPLE:2-[(E)-2-Cyano-1-phenylvinyl]-4,5-bis(4-methoxyphenyl)-1H-imid azole. USE:An anti-inflammatory agent, antipyretic, analgesic agent and antiarthritic agent. PREPARATION:For example, a compound expressed by formula II (R<4a> is R<4> except CN) is subjected to the Wittig reaction to afford the corresponding compound expressed by formula I.
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