| 摘要 |
<p>NEW MATERIAL:A compound (salt) expressed by the formula (R<1> represents H or 1-4C alkyl; R<2> represents aldose residue or aldose residue in which COOH group, OH group, etc., is protected with benzoyl group, etc.; bond of R<2> with camptothecin is glycoside bond between oxygen atom. of A ring of camptothecin and carbon atom. of the 1-position of sugar). EXAMPLE:7-Ethylcamptothecin-10-yl beta-D-glucopyranoside. USE:A remedy against malignant tumor. PREPARATION:For example, 7-ethyl-10-hydroxycamptothecin is reacted with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide in the presence of a basic substance, purified with silica gel column chromatography and then protecting groups thereof are eliminated, as necessary, to afford the compound expressed by the formula.</p> |
