| 摘要 |
PURPOSE:To achieve a determination of a rheumatism factor accurately in a short time, by adding a diagnosis reagent, in which a physiologically active substance is supported on an inactive carrier particle, and a sample to a well to which is bonded a physiologically active substance reactable with the rheuma tism factor. CONSTITUTION:Protein (antigen) prone to antigen-antibody reaction specifically with a rheumatism factor and/or a physiologically active substance such as antibody prone to antigen-antibody reaction with human IgG or human IgM are distributed into a well with an appropriate buffer as solution and coupled to the inner surface thereof by drying. Then, when a diagnosis reagent in which this physiologically active substance is supported on an inactive carrier such as polystyrene and a sample are added to the well, a rheumatism factor contained in serum is bonded to the physiologically active substance by an antigen-antibody reaction to form an agglutination, which is bonded to the physiologically active substance previously immobilized in the well. Thus, the agglutination in the well is quickly coupled to the inner surface of the well to obtain an agglutination image observable with naked eyes quickly.
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