发明名称 |
4-[4-[4-[4-[[2-(2,4-Difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]-methoxy]phenyl]-1-piperazinyl]phenyl]triazolones. |
摘要 |
Novel 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4 -yl] methoxy]phenyl]-1-piperazinyl]phenyl]triazolones of formula <CHEM> wherein Q is N or CH; R is hydrogen, C1-6alkyl or arylC1-6alkyl; and R<1> is hydrogen, C1-6alkyl or arylC1-6alkyl; wherein aryl is phenyl optionally substituted with up to 3 substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy and trifluoromethyl, the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-microbial agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
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申请公布号 |
EP0283992(A2) |
申请公布日期 |
1988.09.28 |
申请号 |
EP19880104473 |
申请日期 |
1988.03.21 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
HEERES, JAN;BACKX LEO JACOBUS JOZEF;VAN DER VEKEN, LOUIS JOZEF ELISABETH |
分类号 |
C07D249/08;A61K31/495;A61P31/04;C07D233/56;C07D233/60;C07D249/12;C07D253/04;C07D295/00;C07D317/00;C07D405/12;C07D405/14;C07D521/00 |
主分类号 |
C07D249/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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