| 摘要 |
<p>By reacting saccharin sodium with isopropyl chloroacetate in dimethylformamide, isopropyl 3-oxo-1,2-benzoisothiazoline-2-acetate 1,1-dioxide is obtained which, by reaction with sodium isopropylate in isopropanol at temperatures between 60 DEG C and the boiling point of the solvent, for a time between 15 minutes and 3 hours, leads to a compound which, when methylated in an aqueous-alcoholic basic medium with dimethyl sulfate, gives an intermediate compound which, when condensed with 2-aminopyridine in xylene, yields 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide which may be used as a non steroidal analgesic and antiinflammatory drug.</p> |
