摘要 |
A process for prepg. the title compd. [Of formula (I), R1 and R2 are each H or acyl, R3 is H comprises (a) decomposing alkyl 2-(2,3,5- tri-O-acyl-beta-D--ribofuranosyl) selenazol-4-carboxylate with ammonia, (b)phosphorization of 2-beta-D-ribofurano silselenazol-4- carboxamide (II) or 2'-O-acyl, 3-O-acyl or 2,4'-diO-acyl derivs., (c) acylation of (II), (d) de-isopropylidenation of 2-(5-O-acyl-2,3-O- isopropylidene-beta-D-ribofuranosyl) selenazol-4-carboxamide or (e) detritylation of 2-(2-Otriphenylmethyl-beta-D-ribofuranosyl) selenazol-4-carboxamide and sepn. of product as salt and non-salt.
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