| 摘要 |
<p>New 19, 11β-bridged steroids having the general formula (I), in which R' signifies a methyl or ethyl residue; R2 signifies a hydrogen or chlorine atom or a C¿1?-C4 alkyl residue; B and G, which are identical or different, signify respectively a hydrogen atom or a C1-C4 alkyl residue, or, together, a second bond between carbon atoms 6 and 7; B and R?2¿ signify a methylene or ethylene group; Z signifies the residue of a pentagonal or hexagonal ring, which may be substituted and may be unsaturated; V signifies a carbocyclic or heterocyclic aryl residue which may be substituted; the ring A signifies (a), in which M and N together signify a second bond, or M signifies a hydrogen atom and N a hydroxy group, in which B, R?2, G, R3¿, D and E are then hydrogen atoms and X an oxygen atom, two hydrogen atoms or a hydroxyimino group N∩OH; R3 and D, which are identical or different, signify respectively a hydrogen atom, a nitrile residue or a C¿1?-C4 alkyl residue, or, together, a methylene or ethylene group; E signifies a hydrogen atom, a C1-C4 alkyl residue; D and E togethe. signify a second bond between the carbon atoms 1 and 2 or, together, a methylene group; or (b) or (c), R?11¿ signifying a hydrogen atom or a C¿1?-C8 alkyl residue. The invention also concerns possibly the pharmaceutically compatible additional salts of said steroids with acids. The new compounds possess valuable pharmacological properties.</p> |
