| 摘要 |
PURPOSE:To continuously obtain the titled compound which is a medicine in high yield, by optically resolving (+ or -)-2-(6-methoxy-2-naphthyl)propionic acid and optically active 1-(p-tolyl)ethylamine in a state of separated crystals in a specific solvent. CONSTITUTION:(+ or -)-2-(6-Methoxy-2-naphthyl)propionic acid and optically active 1-(p-tolyl)ethylamine in an amount within the range of preferably 0.7-2mol., particularly equimolar amount based on the above-mentioned compound are subjected to optical resolution using a nonpolar solvent having >=120 deg.C boiling point, preferably >=8C aliphatic hydrocarbon, e.g. n-octane, n-nonane or n-decane, as a solvent at >=120 deg.C, preferably 120-150 deg.C to afford the aimed compound. Furthermore, the resolution is preferably carried out in an inert gas, e.g. nitrogen atmosphere, so as to avoid formation of by-products.
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