| 摘要 |
NEW MATERIAL:An isoquinoline derivative shown by formula I [R is acyl; R' is lower alkoxy or NR1R2 (R1 is H or lower alkyl; R2 is lower alkyl which may contain substituent group or R1 and R2 together with neighboring N are bonded to form ring which may contain other different atom and/or substituent group)]. EXAMPLE:1-Dimethylamino-3-acetamino-isoquinoline. USE:An anti-inflammatory drug drug and analgesic effective for diseases such as arthritis, lumbago, toothache and heat disease and an antiarrhythmic agent. PREPARATION:A 1-halogeno-isoquniline shown by formula II (X is halogen) is reacted with a nucleophilic compound shown by formula III to give a compound shown by formula I.
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