Beta-lactam compounds and production process thereof.

摘要

Novel beta -lactam compounds of the formula, <CHEM> (wherein OR<1> is a protected or unprotected hydroxyl group; R<2> is C1 to C7 alkyl or aryl; R<3> is hydrogen or a tri-substituted silyl, are produced from azetidinone compounds of the formula, <CHEM> (wherein OR<1> is as defined above; X is an electronegative leaving group) are prepared by reaction with (a) stannylallenes of the formula R<2> CH=C=CH-SnR<7>3 (wherein R<2> is as defined above and R<7> is a C1-C4 alkyl or phenyl) or (b) a metal compound of the formula R<2>-CH(M)C @CH (wherein R<2> is as defined above and M is Mg.halogen, Li, or a titanic or boric acid ester group) to obtain a said beta -lactam compound in which R<3> is hydrogen". The beta -lactam compounds are useful for synthesizing 1 beta -methylcarbapenem compounds.