3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene.

摘要

Indane-, dihydrobenzofurane-, dihydrobenzothiophene-, and indoline- derivatives of the following formula: <CHEM> wherein X, R<1>, R<2>, R<3> and R<4> are as defined in Claim 1, are effective at presynaptic DA receptors, or both at pre- and postsynaptic DA receptors, indicating usefulness in the treatment of disorders of the central nervous system (CNS) such as schizophrenia or Parkinson's disease. The 1-aminomethyl derivatives of Formula I exist as optical isomers, and the useful effects are often found in the single enantiomers to a different degree. A method for the preparation of compounds of Formula I is described.