摘要 |
Compounds of the formula: <IMAGE> wherein R1 is (1) hydrogen, (2) C1 to C4 alkyl, (3) C2 to C4 alkenyl, or (4) NR2R3, wherein R2 and R3 are independently selected from hydrogen, C1 to C4 alkyl and hydroxyl, but R2 and R3 are not simultaneously hydroxyl; X is (1) oxygen, (2) sulfur, (3) SO2, or (4) NR4, wherein R4 is (1) hydrogen, (2) C1 to C6 alkyl, (3) C1 to C6 alkoyl or (4) aroyl; A is selected from C1 to C6 alkylene and C2 to C6 alkenylene; n is 0-4; Y is selected independently at each occurrence from (1) hydrogen, (2) halogen, (3) hydroxy, (4) cyano, (5) halosubstituted alkyl, (6) C1 to C12 alkyl, (7) C2 to C12 alkenyl, (8) C1 to C12 alkoxy, (9) C3 to C8 cycloalkyl, (10) aryl, (11) aryloxy, (12) aroyl, (13) C1 to C12 arylalkyl, (14) C2 to C12 arylalkenyl, (15) C1 to C12 arylalkoxy, (16) C1 to C12 arylthioalkoxy, and substituted derivatives fo (17) aryl, (18) aryloxy, (19) aroyl, (20) C1 to C12 arylalkyl, (21) C2 to C12 arylalkenyl, (22) C1 to C12 arylalkoxy, or (23) C1 to C12 arylthioalkoxy, wherein substituents are selected from halo, nitro, cyano, C1 to C12 alkyl, alkoxy, and halosubstituted alkyl; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C1 to C12, alkoyl are potent inhibitors of 5- and/or 12-lipoxygenase enzymes. Also disclosed are lipoxygenase inhibiting compositions and a method of inhibiting lipoxygenase.
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