| 摘要 |
A steroid derivative of the formula: ST-A-X-R1 wherein ST is a 7 alpha -linked steroid nucleus of the general formula: <IMAGE> wherein the double bond(s) between carbon atoms 6 and 7 and/or carbon atoms 8 and 9 are optional; wherein the aromatic ring A may optionally bear one or two halogen or alkyl substituents; wherein R3 is hydrogen, alkyl, or acyl; wherein R16 is hydrogen, alkyl or hydroxy; wherein either R17 is hydroxy or acyloxy and R27 is hydrogen, alkyl, alkenyl or alkynyl, or R17 and R27 together form oxo (=O); wherein R18 is alkyl; wherein A is alkylene, alkenylene or alkynylene optionally fluorinated and optionally interrupted by -O-, -S-, -SO-, -SO2-, -CO-, -NR-, -NRCO-, -CONR-, -COO-, -OCO- or phenylene, wherein R is hydrogen or alkyl; wherein R1 is hydrogen, alkyl, alkenyl, cycloalkyl, halogenoalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl, arylalkyl, or dialkylaminoalkyl, or R1 is joined to R2 as defined below; and wherein X is -CONR2-, -CSNR2-, -NR12CO-, -NR12CS-, -NR12 CONR2-, <IMAGE> -SO2NR2- or -CO-; or, when R1 is not hydrogen, is -O-, -NR2-, -(NO)R2-, -(PO)R2-, -NR12COO-; -NR12SO2-, -S-, -SO- or -SO2-; wherein R2 is hydrogen or alkyl or R1 and R2 together form alkylene or halogenoalkylene; wherein R12 is hydrogen or alkyl and wherein R22 is hydrogen, cyano or nitro; or a salt thereof when appropriate. |
