PROCESS FOR THE LOADING OF WATER-SWELLABLE WATER- INSOLUBLEPOLYMERS WITH MEDROXYPROGESTERONE ACETATE

摘要

TITLE : "PROCESS FOR THE LOADING OF WATER-SWELLABLE WATER -INSOLUBLE POLYMERS WITH MEDROXYPROGESTERONE ACETATE" A water-swellable, water-insoluble polymer is loaded with methylhydroxyprogesterone acetate (MAP) by: (a) preparing and grinding a mixture of a said polymer and MAP; or (b)(i) preparing a mixture of a said polymer which is stable under the heating to which the mixture is subjected in step (ii) and MAP and (ii) heating the mixture up to the melting temperature of MAP; or (c) swelling a said polymer with a MAP solution capable thereof and drying the resulting swollen polymer/MAP system. The MAP loaded polymer is useful as a pharmaceutical composition.