发明名称 Isolation, purification and sequence determination of cardionatrins
摘要 Four peptides have been isolated from mammalian atria which exhibit potent diuretic, natiuretic and vasodilatory properties. These peptides derive from a common precursor preprocardionatrin of 152 amino acids in a determined sequence. Cardionatrin III and IV, having molecular weights of about 8,000 and 13,700 respectively have been isolated, purified by chromatographic techniques and their amino acid sequence determined.
申请公布号 US4761469(A) 申请公布日期 1988.08.02
申请号 US19870015514 申请日期 1987.02.13
申请人 QUEEN'S UNIVERSITY AT KINGSTON 发明人 DE BOLD, ADOLFO J.
分类号 A61K35/34;A61K38/00;C07K14/58;(IPC1-7):C07K7/10 主分类号 A61K35/34
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