DNA encoding an inactivated IMP dehydrogenase.

摘要

A DNA, which is highly homologus to that of an IMP dehydrogenase gene region and/or its flanking regions and is renderred the function of said gene inactivated, can be produced by the use of recombinant DNA techniques. Said DNA or a vector with said DNA is used to transform a Bacillus strain capable of producing at least one of inosine, xanthosine and guanosine, and the thus obtained inosine producing strain is both high in inosine accumulation and highly stable.