| 摘要 |
Compounds having the general formula <CHEM> in which W is R min or OR min , R min being hydrogen, alkyl, phenyl or benzyl X is (CH2)p-CHR<3> or CHR<3>-(CH2)p- R3<3> is ohosen from various substituents, Y is -NH@-, -@NH-, -NH @-NH, or -NH@-O-, Z is chosen from various of organic groups, and R2 forms, with the carbonyl group to which it is attached, carboxy or various esterified carboxy groups or is the group -NR<8>R<9>. The compounds inhibit the activity of etikephalinases. Intermediates of formula (Wa)2@-Xa-Ya are disclosed in which Wa is alkoxy, phenoxy or benzyloxy <CHEM> and Ya is -NH2 or -NCO. t |
