| 摘要 |
<p>NEW MATERIAL:A compound of formula I [R<1> is (protected)carboxy; R<2> is (protected) hydroxy lower alkyl; R<3> is H or lower alkyl; R<4> is hydroxythiazolyl, hydroxy lower alkylthiazolyl, halo lower alkylthiazolyl, etc.; R<5> is H, imino- protecting group or lower alkaneimidoyl; but when the R<4> is imidazoyl, R<5> is lower alkaneimidoyl] or a salt thereof. EXAMPLE:(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-3-[(2S,4S)-2-(2- hydroxymethylthiazol-4-yl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidin-4-yl ]thio-4- methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester. USE:An antibiotic active against gram-positive bacteria, gram-negative bacteria, etc. PREPARATION:A compound of formula II is reacted with a compound of formula III.</p> |
