Furfuryl derivatives of vinblastine-type bis-indoles, and pharmaceutical compositions containing them

摘要

The invention relates to novel furfuryl derivatives of the general formula (I), <IMAGE> (I) wherein R1 stands for a hydrogen atom or an acetyl group, R2 stands for a hydroxyl or ethyl group of beta -position; R3 means an ethyl group of alpha -position; R4 represents a hydrogen atom; or R3 and R4 together represent an oxygen bridge; and B stands for a hydroxyl of an O-acyl group, as well as their acid addition salts and pharmaceutical preparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations. The compounds of the general formula (I) show a cytostatic activity with less toxicity than that of the commerically available known vinblastine-type bis-indole alkaloid drugs.