NOVEL AMINOAZOLE DERIVATIVE AND ACID ADDITION SALT THEREOF

摘要

NEW MATERIAL:A compound expressed by formula I {A is Ar<1>-D-Ar<2> {Ar is phenyl or thienyl; Ar<2> is phenylene or thienylene; D is C=N-OR<4> (R<4> is H or alkyl), CO, NH, etc.], formula II (R<6> is alkoxy; R<7> is alkyl; R<8> is benzoyl), etc.; B is azole ring; R<1> and R<3> are H or alkyl; R<2> is H, alkyl, arylalkyl or R<9>-G (R<9> is H, alkyl, haloalkyl, aryl, etc.; G is CO, CS, SO2, etc.), etc.} and acid addition salt thereof. EXAMPLE:2-Amino-4-[1-(2-fluoro-4-biphenylyl)ethyl]thiazole. USE:A remedy for autoimmune disease, inflammation, asthma, etc. PREPARATION:For example, an acetone derivative expressed by formula III (Y<1> is eliminative group) is reacted with a thiourea derivative expressed by formula IV in an inert solvent to afford the aimed compound expressed by formula I.